Title Sequence is a game in which two performers invent and sing the theme song for a sitcom about two given or audience-suggested unlikely roommates. The other two performers act out the opening sequence as those two roommates.
- Season 2 episodes: 24, 34
- Season 4 episodes: 07, 18, 20, 27
- Season 5 episodes: 24
- Season 6 episodes: 03, 08
- Season 8 episodes: 02
- Colin Mochrie and Ryan Stiles have always done the acting.