Title Sequence is a game in which two performers invent and sing the theme song for a sitcom about two given or audience-suggested unlikely roommates. The other two performers act out the opening sequence as those two roommates.
- Season 2 episodes: 24, 34
- Season 4 episodes: 07, 18, 20, 27
- Season 5: 1 episode
- Season 6: 2 episodes
- Season 8: 1 episode
- Colin Mochrie and Ryan Stiles always do the acting.